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CAFFEINE ANHYDROUS AR

Suitable for determination of Serum Bilirubin (Confirm to IP/BP)
1,3,7-Trimethylxanthine; Coffeinum

COAs

Packings

100 g (00100)

250 g (00250)

1PW1200200 1PW1200750
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Article No. 02430 Grade AR
Purity 99% CAS No. 58-08-2
Molecular Formula C8H10N4O2 Molecular Weight 194.19
H.S. Code 2939.3000 Shelf Life 60 Months

Physical Properties

Physical state at 20 °C Solid Colour White crystalline
Odour Odorless pH value 6.9
Melting point/ Freezing point [°C] 234 - 236°C Boiling point [°C] 178°C
Density [g/cm3] 1.23 Solubility in water [% weight] 1 gm in 46 mls water
Partition coefficient Log Pow octanol / water at 20°C 0.07

Specifications

Appearance Silky white crystals, white glistering needles or a white crystalline powder Assay (Potentiometric) 98.5% -101.5% (on died basis)
Solubility Sparingly soluble in water, freely soluble in boiling water, slightly soluble in ethanol (96 per cent). It dissolves in concentrated solutions of alkali benzoates or salicylates. Identification -
Identification 'A' & 'B' The spectrum of the sample should be concordant with spectrum of caffeine CRS or with the reference spectrum of caffeine Identification 'A' Melting point - 235 - 237°C
Identification 'C' The precipitate should dissolve Identification 'D' An intense blue color should develops
Identification 'E' LOD - NMT 0.5% Identification 'F' It give the reaction of xanthines
Appearance of solution Solution S should be clear and colorless Insoluble matter in water Max 0.005%
Acidity NMT 0.2 ml of 0.01M NaOH should be required to change the color of indicator to blue Related substance (by HPLC) -
Unspecified impurities NMT 0.1% Total impurities NMT 0.1%
Sulphates Max 0.05% Sulphated ash Max 0.1%
Copper (Cu) Max 0.0002% Iron (Fe) Max 0.0002%
Lead (Pb) Max 0.0002% Zinc (Zn) Max 0.0002%

Safety Information and Hazard Symbols

Exclamation Mark
Symbol: GHS07
 Signal Word: Warning
 Hazardous Statement: H302
 Precaution Statement: P264 - P270 - P301 + P312 - P501
Revision Date: 26-Aug-2026

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